Bas Pennings

Research Technician

Bas.Pennings@radboudumc.nl

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CURRENT POSITION

As a research technician I am supporting the project “Antiviral defence in the vector mosquito Aedes aegypti, induction and suppression of RNA silencing pathways”.

BACKGROUND

Education

Hogeschool van Arnhem en Nijmegen, Nijmegen, The Netherlands. Chemical Laboratory Science – Graduation option Biochemistry. 1996 – 2000.

Professional experience

Research Technician. Radboudumc, Nijmegen, The Netherlands. Department of Orthodontics and Craniofacial Biology (Prof. AM Kuijpers-Jagtman). 2011 – 2014.

At the department of Orthodontics and Craniofacial Biology I supported the project “Induction of cyto protective proteins as a new strategy against hypertrophic scar formation by oxidative stress and inflammation”.

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Research Technician. University Medical Center St Radboud, Nijmegen, The Netherlands. Department of Pharmacology and Toxicology (Prof. Smits and Prof. Russel). 2005 – 2010.

At the department of Pharmacology and Toxicology I was part of a team researching fundamental heme oxygenase biology focusing on the reduction of wound contraction.

Project title: “Targeting the heme heme oxygenase system: a novel therapeutic approach for the reduction of wound contraction”.

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Reseach Technician. Radboud University Nijmegen, The Netherlands. Department of Molecular Biology (Prof. Henk Stunnenberg). 2000 – 2004.

At the department of Molecular Biology (investigating the fundamental mechanisms of transcriptional regulation and chromosome structures) I supported a research team that looked into the underlying mechanisms of leukemia with the focus on transcriptional regulation of gene expression by hormone receptors. Much of the work done involved elucidating the histone code surrounding promoter regions using the ChIP technique coupled to quantitative real time PCR.

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Internship. Radboud University Nijmegen, The Netherlands. Department of Biochemistry (Dr. Toin van Kuppevelt). 1999 – 2000.

At the department of Biochemistry I performed my traineeship and looked into possible uses of scFv antibody fragments in heparan sulfate research and made the first steps in finding out what (heparan sulfate) structure a specific single chain antibody recognizes in the Wilms’ tumor cell line.

PUBLICATIONS

Histone-derived piRNA biogenesis depends on the ping-pong partners Piwi5 and Ago3 in Aedes aegypti. Nucleic Acids Research.

Erika Girardi, Pascal Miesen, Bas Pennings, Lionel Frangeul, Maria-Carla Saleh, Ronald van Rij

Vascular and metabolic effects of the haem oxygenase-1 inducer haem arginate in subjects with the metabolic syndrome: A translational cross-over study. Diabetes & Vascular Disease Research.

Douwe Dekker, Mirrin J Dorresteijn, Wilbert HM Peters, Ab Bilos, Sebastiaan WC Pennings, Frank ADTG Wagener, Paul Smits

Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase. Frontiers in Pediatrics 2015.

Rosa L.E. Loon, Beatrijs Bartelds, Frank A.D.T.G. Wagener, Nada Affara, Saffloer Mohaupt, Hans Wijnberg, Sebastiaan W.C. Pennings, Janny Takens, Rolf M.F. Berger

Cytoprotective responses in HaCaT keratinocytes exposed to high doses of curcumin. Experimental Cell Research 2015.

Ditte M.S. Lundvig, Ph.D., Sebastiaan W Pennings, Katrien M Brouwer, Matilda Mtaya-Mlangwa, Emeria A Mugonzibwa, Anne Marie Kuijpers-Jagtman, Frank A Wagener, Dr. Johannes Von den Hoff

Cell-Type-Specific Down-Regulation of Heme Oxygenase-1 by Lipopolysaccharide via Bach1 in Primary Human Mononuclear Cells. Free Radical Biology and Medicine 10.1016/j.freeradbiomed.2014.10.579.

Mirrin J. Dorresteijn, Ananta Paine, Eva Zilian, Maaike G.E. Fenten, Eileen Frenzel, Sabina Janciauskiene, Constanca Figueiredo, Britta Eiz-Vesper, Rainer Blasczyk, Douwe Dekker, Bas Pennings, Alwin Scharstuhl, Paul Smits, Jan Larmann, Gregor Theilmeier, Johannes G. van der Hoeven, Frank A.D.T.G. Wagener, Peter Pickkers, Stephan Immenschuh

Curcumin induces differential expression of cytoprotective enzymes but similar apoptotic responses in fibroblasts and myofibroblasts. Experimental Cell Research 2014 – 10.1016/j.yexcr.2014.10.006.

Ditte M.S. Lundvig, Sebastiaan W.C. Pennings, Katrien M. Brouwer, Matilda Mtaya-Mlangwa, Emeria A. Mugonzibwa, Anne Marie Kuijpers-Jagtman, Johannes W. Von den Hoff, Frank A.D.T.G. Wagener

Delayed cutaneous wound closure in HO-2 deficient mice despite normal HO-1 expression. Journal of Cellular and Molecular Medicine 2014.

Lundvig Ditte, Scharstuhl Alwin, Pennings Bas, te Paske Jeroen, van Rheden René, Coby van Run-van Breda, Regan Raymond, Russel Frans, Carels Carine, Jaap Maltha, and Frank Wagener

Heme Oxygenase-1 and Breast Cancer Resistance Protein Protect Against heme-induced toxicity. Current pharmaceutical design 10/2012.

Frank A D T G Wagener, Anita C A Dankers, Frank van Summeren, Alwin Scharstuhl, Jeroen J M W van den Heuvel, Jan B Koenderink, Sebastiaan W C Pennings, Frans G M Russel, Rosalinde Masereeuw

Modulating TLR responses in systemic sclerosis via heme oxygenase-1. Annals of The Rheumatic Diseases – ANN RHEUM DIS. 01/2010; 69(2).

L van Bon, A Scharstuhl, B Pennings, R J F Huijbens, M H Wenink, K C M Santegoets, M Vonk, W van den Berg, F Wagener, T R D J Radstake

Involvement of VDAC, Bax and ceramides in the efflux of AIF from mitochondria during curcumin-induced apoptosis. PLoS ONE 02/2009; 4(8):e6688.

Alwin Scharstuhl, Henricus A M Mutsaers, Sebastiaan W C Pennings, Frans G M Russel, Frank A D T G Wagener

DNA methylation immediately adjacent to active histone marking does not silence transcription. Nucleic Acids Research 02/2007; 35(3):801-11.

Arie B Brinkman, Sebastiaan W C Pennings, Georgia G Braliou, Luc E G Rietveld, Hendrik G Stunnenberg

Histone modification patterns associated with the human X chromosome. EMBO Reports 07/2006; 7(6):628-34.

Arie B Brinkman, Thijs Roelofsen, Sebastiaan W C Pennings, Joost H A Martens, Thomas Jenuwein, Hendrik G Stunnenberg
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