Pascal Miesen

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PhD student

p.miesen@ncmls.ru.nl

CURRENT POSITION

I am currently working on the role of Piwi-interacting RNAs (piRNAs) in mediating antiviral immunity in Aedes mosquitoes which transmit a number of relevant human pathogens among which Dengue virus. Virus-derived piRNAs have recently been discovered in these animals and I am interested in their biogenesis as well as in their mode of action.
Furthermore, I am intrigued by the microRNA pathway and its impact on the immune response both in invertebrate and vertebrate hosts.

BACKGROUND

Education

PhD thesis (2011 to present)
Radboud University Medical Center, Nijmegen, The Netherlands

Master of Science in Molecular Mechanisms of Disease (2009-2011)
Radboud University Medical Center, Nijmegen, The Netherlands

Bachelor of Science in Medical Biology (2006-2009)
Radboud University Nijmegen, Faculty of Science, Nijmegen, The Netherlands

Professional experience

Final Master’s Internship (January 2011 – July 2011)

Genome-wide microRNA bining site discovery in Murine Cytomegalovirus

Dr. Amy H. Buck
University of Edinburgh, United Kingdom

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First Master’s Internship (January 2010- August 2010)

The role of Ubiquitylation in normal and malignant Hematopoiesis

Dr. Bert A. van der Reijden
Radboud University Medical Centre, Nijmegen, The Netherlands

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Bachelor’s Internship (March 2009 – June 2009)

MicroRNA expression during Xenopus embryogenesis

Prof. Gert-Jan Veenstra
Nijmegen Centre for Molecular Life Sciences

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PUBLICATIONS

Libri V., Miesen P., van Rij R.P. & Buck A.H. (2013) Regulation of microRNA biogenesis and turnover by animals and their viruses. Cell Mol Life Sci. Jan 26. [Epub ahead of print]
doi10.1007/s00018-012-1257-1

Vodovar N., Bronkhorst A.W., van Cleef K.W., Miesen P., Blanc H., van Rij R.P. & Saleh M.C. (2012). Arbovirus-derived piRNAs exhibit a ping-pong signature in mosquito cells. PLoS One. 7(1):e30861. doi: 10.1371/journal.pone.0030861.

Libri V., Helwak A., Miesen P., Santhakumar D., Borger J.G., Kudla G., Grey F., Tollervey D. & Buck A.H. (2012). Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target. Proc Natl Acad Sci USA,109:279-84.

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